prednisolone
prednisolone · by elkins sinn
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$0.59 /mL
Lower-cost optionsSave up to 60%
This medication~$0.59
Cheapest in class · decadron w/ xylocaine~$0.23
Overview
Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Prednisolone USP is a white to practically white, odorless, crystalline powder, soluble in methanol and in dioxane, sparingly soluble in acetone and in alcohol, slightly soluble in chloroform, very slightly soluble in water. It is designated chemically as pregna-1,4-diene-3,20-dione,11,17,21-trihydroxy-, (11ß)-. The structural formula is represented below: C 21 H 28 O 5 M.W. 360.45 Prednisolone Tablets, USP 5 mg for oral administration contain the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, crospovidone, D&C Yellow No. 10 Aluminum Lake HT, docusate sodium, FD&C Yellow No. 6 Aluminum Lake, magnesium stearate and sodium benzoate. FDA approved dissolution test specifications differ from USP. structure
How to use
The initial dosage of prednisolone tablets may vary from 5 mg to 60 mg per day depending on the specific disease entity being treated. In situations of less severity, lower doses will generally suffice, while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period of time there is a lack of satisfactory clinical response, prednisolone should be discontinued and the patient transferred to other appropriate therapy. IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small increments at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. It should be kept in mind that constant monitoring is needed in regard to drug dosage. Included in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient’s individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment; in this…
Side effects
Fluid and Electrolyte Disturbances Sodium retention. Fluid retention. Congestive heart failure in susceptible patients. Potassium loss. Hypokalemic alkalosis. Hypertension. Musculoskeletal Muscle weakness. Steroid myopathy. Loss of muscle mass. Osteoporosis. Vertebral compression fractures. Aseptic necrosis of femoral and humeral heads. Pathologic fracture of long bones. Gastrointestinal Peptic ulcer with possible perforation and hemorrhage. Pancreatitis. Abdominal distention. Ulcerative esophagitis. Dermatologic Impaired wound healing. Thin fragile skin. Petechiae and ecchymoses. Facial erythema. Increased sweating. May suppress reactions to skin tests. Neurological Convulsions. Increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment. Vertigo. Headache. Endocrine Menstrual irregularities. Development of Cushingoid state. Suppression of growth in children. Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery, or illness. Decreased carbohydrate tolerance. Manifestations of latent diabetes mellitus. Increased requirements for insulin or oral hypoglycemic agents in diabetics. Ophthalmic Posterior subcapsular cataracts. Increased intraocular pressure. Glaucoma. Exophthalmos. Metabolic Negative nitrogen balance due to protein catabolism. To report SUSPECTED ADVERSE REACTIONS, contact…
Warnings
Important safety information
In patients on corticosteroid therapy subjected to unusual stress increased dosage of rapidly acting corticosteroids before, during, and after the stressful situation is indicated. Immunosuppression and Increased Risk of Infection Corticosteroids, including prednisolone, suppress the immune system and increase the risk of infection with any pathogen, including viral, bacterial, fungal, protozoan, or helminthic pathogens. Corticosteroids can: Reduce resistance to new infections Exacerbate existing infections Increase the risk of disseminated infections Increase the risk of reactivation or exacerbation of latent infections Mask some signs of infection Corticosteroid-associated infections can be mild but can be severe and at times fatal. The rate of infectious complications increases with increasing corticosteroid dosages. Monitor for the development of infection and consider prednisolone withdrawal or dosage reduction as needed. Do not administer prednisolone by an intraarticular, intrabursal, intratendinous, or intralesional route in the presence of acute local infection. Tuberculosis If prednisolone is used to treat a condition in patients with latent tuberculosis or tuberculin reactivity, reactivation of tuberculosis may occur. Closely monitor such patients for reactivation. During prolonged prednisolone therapy, patients with latent tuberculosis or tuberculin reactivity…
Drug class
May treat
Dosage forms
TABLET
Ways to save
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Frequently asked questions
- What is Prednisolone?
- Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Prednisolone USP is a white to practically white, odorless, crystalline powder, soluble in methanol and in dioxane, sparingly soluble in acetone and in alcohol, slightly soluble in chloroform, very slightly soluble in water. It is designated chemically as pregna-1,4-diene-3,20-dione,11,17,21-trihydroxy-, (11ß)-. The structural formula is represented below: C 21 H 28 O 5 M.W. 360.45 Prednisolone Tablets, USP 5 mg for oral administration contain the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, crospovidone, D&C Yellow No. 10 Aluminum Lake HT, docusate sodium, FD&C Yellow No. 6 Aluminum Lake, magnesium stearate and sodium benzoate. FDA approved dissolution test specifications differ from USP. structure
- What does Prednisolone treat?
- Prednisolone (Prednisolone) is indicated for adrenal insufficiency, anemia, hemolytic, asthma, berylliosis, brain neoplasms, colitis, ulcerative, per its drug-label indications. This is general reference, not medical advice.
- How much does Prednisolone cost?
- Prednisolone has a typical acquisition cost of about $0.59 per ml, based on CMS NADAC data. A lower-cost same-class option, Decadron W/ Xylocaine, runs about $0.23 — see ways to save below.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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